Accomplished sports writer Mitch Albom (Hank Azaria) feels that his life is lacking, despite his success. When Mitch watches a television interview with his former university professor, Morrie Schwartz (Jack Lemmon), he is moved to reconnect with his old mentor, who is struggling with Lou Gehrig's disease. As Mitch and Morrie get reacquainted, they engage in thoughtful conversations about a variety of significant topics, including love, happiness and death.